Research

Our research focusses on development and application neuroimaging and modelling approaches to study brain physiology. The group is composed of multiple PIs with research spanning measurements of cerebrovascular (dys)function, brain microstructure, brain circuits and connectivity and glymphatic function. The group predominantly uses magnetic resonance imaging, however other approaches such as EEG, multiphoton microscopy, and functional ultrasound are developed and used.

Highlighted

Open collaborative writing with Manubot

Daniel S. Himmelstein, Vincent Rubinetti, David R. Slochower, Dongbo Hu, Venkat S. Malladi, Casey S. Greene, Anthony Gitter

PLOS Computational Biology  ·  04 Dec 2020  ·  doi:10.1371/journal.pcbi.1007128

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2025

Comparison of the Novel Thrombolytic Constitutively Active ADAMTS13 With Clinical Thrombolytics in a Murine Stroke Model

Lucy Roberts, Graham Coutts, Ben R. Dickie, Craig J. Smith, Kieron South, Stuart M. Allan

Stroke  ·  01 Jun 2025  ·  doi:10.1161/STROKEAHA.125.050848

Early metabolic changes in the brain of Alzheimer’s disease rats are driven by GLAST+ cells

William J Morrey, Kelly Ceyzériat, Quentin Amossé, Aurélien M Badina, Ben Dickie, Ingo Schiessl, Stergios Tsartsalis, Philippe Millet, Hervé Boutin, Benjamin B Tournier

Journal of Cerebral Blood Flow & Metabolism  ·  07 Feb 2025  ·  doi:10.1177/0271678X251318923

2024

Neuroinflammation and blood-brain barrier breakdown in acute, clinical intracerebral hemorrhage

Olivia A Jones, Saffwan Mohamed, Rainer Hinz, Alastair Paterson, Oluwaseun A Sobowale, Ben R Dickie, Laura M Parkes, Adrian R Parry-Jones

Journal of Cerebral Blood Flow & Metabolism  ·  03 Oct 2024  ·  doi:10.1177/0271678X241274685

A systematic review of normal tissue neurovascular unit damage following brain irradiation—Factors affecting damage severity and timing of effects

Annet Nakkazi, Duncan Forster, Gillian A Whitfield, Douglas P Dyer, Ben R Dickie

Neuro-Oncology Advances  ·  01 Jan 2024  ·  doi:10.1093/noajnl/vdae098

2023

A community‐endorsed open‐source lexicon for contrast agent–based perfusion MRI: A consensus guidelines report from the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI)

Ben R. Dickie, Zaki Ahmed, Jonathan Arvidsson, Laura C. Bell, David L. Buckley, …, Petra J. van Houdt, Steven Sourbron, Michael J. Thrippleton, Chad Quarles, Ina N. Kompan

Magnetic Resonance in Medicine  ·  13 Oct 2023  ·  doi:10.1002/mrm.29840

Blood–brain barrier water exchange measurements using contrast‐enhanced ASL

Elizabeth Powell, Ben R. Dickie, Yolanda Ohene, Mark Maskery, Geoff J. M. Parker, Laura M. Parkes

NMR in Biomedicine  ·  04 Sep 2023  ·  doi:10.1002/nbm.5009

2022

In vivo methods for imaging blood–brain barrier function and dysfunction

William James Harris, Marie-Claude Asselin, Rainer Hinz, Laura Michelle Parkes, Stuart Allan, Ingo Schiessl, Herve Boutin, Ben Robert Dickie

European Journal of Nuclear Medicine and Molecular Imaging  ·  28 Nov 2022  ·  doi:10.1007/s00259-022-05997-1

Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI

Ben R Dickie, Tao Jin, Ping Wang, Rainer Hinz, William Harris, Hervé Boutin, Geoff JM Parker, Laura M Parkes, Julian C Matthews

Journal of Cerebral Blood Flow & Metabolism  ·  23 Jun 2022  ·  doi:10.1177/0271678X221108841

2021

Genotype and Th2 cells control monocyte to tissue resident macrophage differentiation during nematode infection of the pleural cavity

Conor M Finlay, James E Parkinson, Brian HK Chan, Jesuthas Ajendra, Alistair Chenery, …, Louis Boon, Andrew S MacDonald, Joanne E Konkel, Dominik Rückerl, Judith E Allen

Cold Spring Harbor Laboratory  ·  19 Dec 2021  ·  doi:10.1101/2021.12.17.472661

In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease

Eugene Kim, Davide Di Censo, Mattia Baraldo, Camilla Simmons, Ilaria Rosa, …, Clive Ballard, Ben R. Dickie, Steven C. R. Williams, Richard Killick, Diana Cash

Scientific Reports  ·  14 Jun 2021  ·  doi:10.1038/s41598-021-91899-5

A Systematic Review of Glucose Transport Alterations in Alzheimer's Disease

Natalia Kyrtata, Hedley C. A. Emsley, Oli Sparasci, Laura M. Parkes, Ben R. Dickie

Frontiers in Neuroscience  ·  20 May 2021  ·  doi:10.3389/fnins.2021.626636

Sources of systematic error in DCE‐MRI estimation of low‐level blood‐brain barrier leakage

Cameron Manning, Michael Stringer, Ben Dickie, Una Clancy, Maria C. Valdés Hernandez, …, Laura M. Parkes, Geoff J. M. Parker, Ian Marshall, Joanna M. Wardlaw, Michael J. Thrippleton

Magnetic Resonance in Medicine  ·  18 May 2021  ·  doi:10.1002/mrm.28833

Alzheimer's disease pathology is associated with earlier alterations to blood–brain barrier water permeability compared with healthy ageing in TgF344‐AD rats

Ben R. Dickie, Hervé Boutin, Geoff J. M. Parker, Laura M. Parkes

NMR in Biomedicine  ·  15 Mar 2021  ·  doi:10.1002/nbm.4510

In vivomulti-parametric manganese-enhanced MRI for detecting senile plaques in rodent models of Alzheimer’s disease

Eugene Kim, Davide Di Censo, Mattia Baraldo, Camilla Simmons, Ilaria Rosa, …, Clive Ballard, Ben R Dickie, Steven CR Williams, Richard Killick, Diana Cash

Cold Spring Harbor Laboratory  ·  14 Jan 2021  ·  doi:10.1101/2021.01.12.426392

2020

Characterisation of microvessel blood velocity and segment length in the brain using multi-diffusion-time diffusion-weighted MRI

Lauren A Scott, Ben R Dickie, Shelley D Rawson, Graham Coutts, Timothy L Burnett, Stuart M Allan, Geoff JM Parker, Laura M Parkes

Journal of Cerebral Blood Flow & Metabolism  ·  16 Dec 2020  ·  doi:10.1177/0271678X20978523

Open collaborative writing with Manubot

Daniel S. Himmelstein, Vincent Rubinetti, David R. Slochower, Dongbo Hu, Venkat S. Malladi, Casey S. Greene, Anthony Gitter

PLOS Computational Biology  ·  04 Dec 2020  ·  doi:10.1371/journal.pcbi.1007128

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.

Manubot

Manuscript Source

Website

open-science collaboration

Measuring water exchange across the blood-brain barrier using MRI

Ben R. Dickie, Geoff J.M. Parker, Laura M. Parkes

Progress in Nuclear Magnetic Resonance Spectroscopy  ·  01 Feb 2020  ·  doi:10.1016/j.pnmrs.2019.09.002

Constructing knowledge graphs and their biomedical applications

David N. Nicholson, Casey S. Greene

Computational and Structural Biotechnology Journal  ·  01 Jan 2020  ·  doi:10.1016/j.csbj.2020.05.017

2019

Water-exchange MRI detects subtle blood-brain barrier breakdown in Alzheimer's disease rats

Ben R. Dickie, Matthias Vandesquille, José Ulloa, Hervé Boutin, Laura M. Parkes, Geoff J.M. Parker

NeuroImage  ·  01 Jan 2019  ·  doi:10.1016/j.neuroimage.2018.09.030

2018

Sci-Hub provides access to nearly all scholarly literature

Daniel S Himmelstein, Ariel Rodriguez Romero, Jacob G Levernier, Thomas Anthony Munro, Stephen Reid McLaughlin, Bastian Greshake Tzovaras, Casey S Greene

eLife  ·  01 Mar 2018  ·  doi:10.7554/eLife.32822

2017

The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant Ktrans in cervical cancer is explained by plasma flow rather than vessel permeability

Ben R Dickie, Chris J Rose, Lucy E Kershaw, Stephanie B Withey, Bernadette M Carrington, Susan E Davidson, Gillian Hutchison, Catharine M L West

British Journal of Cancer  ·  27 Apr 2017  ·  doi:10.1038/bjc.2017.121

2015

Improved accuracy and precision of tracer kinetic parameters by joint fitting to variable flip angle and dynamic contrast enhanced MRI data

Ben R. Dickie, Anita Banerji, Lucy E. Kershaw, Andrew McPartlin, Ananya Choudhury, Catharine M. West, Chris J. Rose

Magnetic Resonance in Medicine  ·  19 Oct 2015  ·  doi:10.1002/mrm.26013